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Title: Application of FT-IR spectroscopy for determination of clarithromycin in pharmaceuticals
Authors: Likhtarovich, E. S.
Lugin, V. G.
Keywords: ИК-Фурье спектроскопия
определение кларитромицина
качественный анализ
количественный анализ
фармацевтические препараты
Issue Date: 2014
Publisher: BSTU
Citation: Likhtarovich, E. S. Application of FT-IR spectroscopy for determination of clarithromycin in pharmaceuticals / E. S. Likhtarovich, V. G. Lugin // Proceedings of BSTU. No. 4. – Minsk : BSTU, 2014. – P. 185-187
Description: Method for the qualitative and quantitative assessment of clarithromycin – macrolide antibiotic – in pharmaceutical formulations was developed by using Fourier-transform infrared (FT-IR) transmission spectroscopy for quality control. The calibration model was developed based on simple Beer's law using the FT-IR carbonyl region (C=O) from 1,750 to 1,675 cm ?1 . Statistical analysis of the results was developed by using TQ Analyst program and based on the least square method. The good coefficient of determination was achieved R 2 = 0.9973. Recovery was achieved from 98 to 106%. The method based on the FT-IR spectroscopy for the quantitative analysis of clarithromycin in pharmaceutical formulations is a fast and promising technique.
Appears in Collections:2014, № 4

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