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https://elib.belstu.by/handle/123456789/14712| Title: | Application of FT-IR spectroscopy for determination of clarithromycin in pharmaceuticals |
| Authors: | Likhtarovich, E. S. Lugin, V. G. |
| Keywords: | ИК-Фурье спектроскопия кларитромицин определение кларитромицина качественный анализ количественный анализ фармацевтические препараты |
| Issue Date: | 2014 |
| Publisher: | BSTU |
| Citation: | Likhtarovich, E. S. Application of FT-IR spectroscopy for determination of clarithromycin in pharmaceuticals / E. S. Likhtarovich, V. G. Lugin // Proceedings of BSTU. No. 4. – Minsk : BSTU, 2014. – P. 185-187 |
| Abstract: | Method for the qualitative and quantitative assessment of clarithromycin – macrolide antibiotic – in pharmaceutical formulations was developed by using Fourier-transform infrared (FT-IR) transmission spectroscopy for quality control. The calibration model was developed based on simple Beer's law using the FT-IR carbonyl region (C=O) from 1,750 to 1,675 cm ?1 . Statistical analysis of the results was developed by using TQ Analyst program and based on the least square method. The good coefficient of determination was achieved R 2 = 0.9973. Recovery was achieved from 98 to 106%. The method based on the FT-IR spectroscopy for the quantitative analysis of clarithromycin in pharmaceutical formulations is a fast and promising technique. |
| URI: | https://elib.belstu.by/handle/123456789/14712 |
| Appears in Collections: | 2014, № 4 |
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