Synthesis of Novel 1,2,6-Trisubstituted Indoles Based on Cyclohexenone Scaffold

Abstract

New methods of construction of heterocyclic systems are always attracting the interest from organic and medicinal chemists because such substances have significant potential in drug discovery. In this field indoles synthesis occupies a prominent place because of the high biological activity of indoles derivatives. The transformation of γ,δ-unsaturated ketones represents a good method for making pyrrole and indole core. In our work we focused on creating of indole core based on cyclohex-2-enone scaffold.