Preparative synthesis of fragrance substances based on vanillin and veratraldehyde

Abstract

Methods of reception of fragrance substances are defined on the basis of vanillin and veratraldehyde by aldol-crotonic condensation with aliphatic and aromatic ketones (acetone, methylethylketone, heptanone-2, ?-ionone, acetophenone, p-methylacetophenone, p-acetyl-anisole). Distinctive feature of the given technique is the use of methanol as solvent and the replacement of potassium hydroxide on sodium hydroxide. For allocation of products of condensation from methanolic solution it is expedient to use 5%-s' solutions of hydrochloric acid instead of acetic acid that allows to receive purer product and raises its yield up to 80–90%. With the help of Infrared Spectroscopy the presence of the functional groups in the received substances was proved.